Endocrine Abstracts

Objective: The aim of this study is the characterizing of genetic variation in PvuII and XbaI polymorphisms of the ESR1 gene associated with age-dependent endocrine, metabolic and cognitive changes in a representative sample of Romanian population stratified by age and sex.Subjects and methods: Subjects, both genders aged between 20 and 80 yr were assigned to three lots 1) 177 subjects aged 55–80 years with moderately cognitive impairment (MCI) (MMS...

Objective: The aim of this study was the identification of eNOS (G894T), p22phox (−930 A/G) and apoE gene polymorphisms associated with the impact of age-dependent endocrine changes.Subjects and methods: Subjects, both genders, were recruited and classified into the three groups: (1) 100 subjects aged 55–80+ years with mild cognitive impairment (MCI) (MMSE<28); (2) 165 age-matched subjects without cognitive impairment (MMSE>...

Objective: An on-going epidemiological populational study examined hormone balance during aging in women, and – whether there was a difference in endogenous serum sex hormone levels between a postmenopausal women group with moderately cognitive impairment and healthy age-mached women group.Subjects and methods: One hundred and sixty-three women aged 25 to 80 years were classified into three groups: (1) 44 subjects aged 55–80 years with moderate...

Objective: We previously found an association between eNOS(G894T) polymorphism and components of metabolic syndrome (MetS); thus, we investigated the metabolic–endocrine changes in postmenopausal women with incipient MetS and the interaction with the polymorphisms of eNOS-G894T, p22phox-930 A/G, CETP TaqIB and ESR1 (PvuII and XbaI) genes.Methods: postmenopausal women aged between 60 and 80 years from a population-based study were classified into the...